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Progestins in birth control pills are sometimes grouped by generation. Food and Drug Administration. The original manufacturer, Upjohn , applied repeatedly for approval. FDA advisory committees unanimously recommended approval in , and , as did the FDA's professional medical staff, but the FDA repeatedly denied approval. High-dose oral and intramuscular MPA monotherapy has been studied in the treatment of prostate cancer but was found to be inferior to monotherapy with cyproterone acetate or diethylstilbestrol. MPA was investigated by InKine Pharmaceutical, Salix Pharmaceuticals, and the University of Pennsylvania as a potential anti-inflammatory medication for the treatment of autoimmune hemolytic anemia , Crohn's disease , idiopathic thrombocytopenic purpura , and ulcerative colitis , but did not complete clinical development and was never approved for these indications.

MPA has been found to be effective in the treatment of manic symptoms in women with bipolar disorder. MPA has been used to reduce aggression and spraying in male cats. From Wikipedia, the free encyclopedia.

Not to be confused with progesterone , a natural and bioidentical progestogen. US : X Contraindicated. IUPAC name.

Interactive image. See also: Steroidogenesis inhibitor and Neurosteroidogenesis inhibitor. See also: List of progestogens , Progestogen ester , List of progestogen esters , Steroidal antiandrogen , and List of steroidal antiandrogens. See also: List of progestogens available in the United States. January Archived from the original on Retrieved 31 March Steroid Biochem.

Archived from the original on 24 December Retrieved 8 December Martindale: The Complete Drug Reference 36th ed. London: Pharmaceutical Press. Molecular Endocrinology. Frontiers in Gynecologic and Obstetric Investigation.

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Archived from the original on 20 May Roberts 7 May Hormone replacement therapy. Elsevier Science. Drug discovery: a history. New York: Wiley. World Health Organization. April Archived PDF from the original on 13 December International Drug Price Indicator Guide. British Medical Association. Wayne Meikle 1 June Hormone Replacement Therapy. World J Pharm Pharm Sci. Practical Management of Gynecological Problems.

JP Medical Ltd. Retrieved 22 December Retrieved Archived PDF from the original on Meyler's side effects of endocrine and metabolic drugs. Amsterdam: Elsevier Science. A review". Cancer Treat. Advances in Pediatrics. Hair and Hair Diseases. Waveland Press. Contraceptive technology 20th revised ed. New York: Ardent Media.

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United States. Contraceptive Technology 18th rev. Obstetrics and Gynecology. Contraceptive Technology 16th rev. New York: Irvington Publishers. Contraceptive Technology 17th rev. Archived from the original PDF on February 25, Contraceptive Technology 19th rev. Family Planning Perspectives.

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A Clinical Guide for Contraception 4th ed. Yen and Jaffe's Reproductive Endocrinology 5th ed. Philadelphia: Elsevier Saunders. Seminars in Reproductive Medicine. Position paper on clinical use, effectiveness and side effects". The British Journal of Family Planning. International Journal of Cancer. September Reduced risk of ectopic pregnancy. Compared with women who use no contraceptive at all, women who use DMPA have a reduced risk for having an ectopic pregnancy. Although the overall risk of pregnancy and thus ectopic pregnancy is lowered by DMPA, the possibility of an ectopic pregnancy should be excluded if a woman using DMPA becomes pregnant.

One study showed that 1. Nursing Times. Archived from the original on 26 August National Institute for Health and Clinical Excellence.

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Archived from the original PDF on Primary Care Commissioning. Archived PDF from the original on 10 August Postgraduate Medicine. Journal of Women's Health. Current Opinion in Obstetrics and Gynecology. United States Food and Drug Administration. Archived from the original on 16 November Elsevier Health Sciences.

Tiziani 1 June Havard's Nursing Guide to Drugs. Leidenberger 17 April Medical Eligibility Criteria for Contraceptive Use 3rd ed. Archived from the original PDF on June 19, Merck Manual. Neurosteroids and the Nervous System. Archived from the original on 5 November Rev Endocr Metab Disord.

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  4. Journal of Thrombosis and Haemostasis. Aronson 15 October Perhaps surprisingly, a consensus seems to be emerging that depot medroxyprogesterone acetate implants do not in fact result in an increase in the incidence of depression or in the severity of pre-existing depression, even after 1 or 2 years, nor do they cause significant weight gain.

    Progress in Human Reproduction Research 23 : 2—3. Lobo 5 June Int J Fertil Womens Med. Despite the efficacy and increasing acceptability of these long-term methods, some clinicians and women are reluctant to use them because of concerns regarding reduction in bone density with DMPA, and depressive symptoms and body weight issues with both injectables and implants. Recent multicenter experience showed no increase in depressive symptoms after 1 year's DMPA use and 2 years' Norplant use, even among users with the highest mean depressive symptom scores pre-therapy.

    Another common patient tolerability concern reported with hormonal contraception is the effect on mood [95]. The majority of published reports indicate that DMPA does not cause depressive symptoms. Other reports in various settings, including a private practice [96], adolescent clinics [97,98], a psychiatric hospital [99] and inner-city family-planning clinics [,], have not found an adverse effect of DMPA on depression.

    Although history of mood symptoms prior to OC use may predispose a subgroup of women to negative mood changes, the data for DMPA suggest that even women who have depressive symptoms prior to treatment can tolerate therapy with no exacerbation of these symptoms. Handbook of Neuroendocrinology. Academic Press. ACP Press. Trends Endocrinol. Annual Review of Public Health. Committee Opinion ". June Family Planning.

    Clinical Endocrinology.